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Contribution of Persistent Organic Pollutant Exposure to the Adipose Tissue Oxidative Microenvironment in an Adult Cohort: A Multipollutant Approach

Artículos Científicos

Despite growing in vitro and in vivo evidence of the putative role of persistent organic pollutants (POPs) in the induction of oxidative damage in cell structures, this issue has been poorly addressed from an epidemiologic perspective. The aim of this study was to explore associations between adipose tissue POP concentrations and the in situ oxidative…

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Exploring available options in characterising the health impact of industrially contaminated site

Artículos Científicos

Industrially contaminated sites (ICS) are of high concern from an environmental public health perspective, since industrial plants may produce a widespread contamination that can result in several health impacts on the populations living in their neighbourhood. The objective of this contribution is to briefly explore available options in studying the health impact of ICS, mainly…

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La calidad en el Bloque Quirúrgico del Hospital Clínico San Cecilio. La perspectiva del cliente interno

Artículos Científicos

Objetivo Evaluar la calidad de los servicios prestados por el Bloque Quirúrgico (BQ) del Hospital Clínico Universitario San Cecilio (HUSC), desde el punto de vista del personal sanitario del hospital. Material y métodos Emplazamiento: Andalucía. Participantes: 134 profesionales con contacto con el BQ del HUSC. Instrumento: cuestionario de elaboración propia, con las siguientes dimensiones: accesibilidad,…

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Endometrial cancer risk prediction including serum-based biomarkers: Results from the EPIC cohort

Artículos Científicos

Endometrial cancer risk prediction models including lifestyle, anthropometric, and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we investigated the improvement…

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Priorities and needs for research on urban interventions targeting vector-borne diseases: rapid review of scoping and systematic reviews

Artículos Científicos

This paper highlights the critical importance of evidence on vector-borne diseases (VBD) prevention and control interventions in urban settings when assessing current and future needs, with a view to setting policy priorities that promote inclusive and equitable urban health services. Research should produce knowledge about policies and interventions that are intended to control and prevent…

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Assessing Potentially Inappropriate Prescribing in Community-Dwelling Older Patients Using the Updated Version of STOPP-START Criteria: A Comparison of Profiles and Prevalences with Respect to the Original Version

Artículos Científicos

Emerging and changing evidence made it necessary to update STOPP-START criteria, and version 2 was published recently. In this study the objectives were to determine the prevalence of potentially inappropriate medication prescribing (PIM) in primary care using STOPP versions 1 (v1) and 2 (v2), as well as 2012 AGS Beers criteria, and analyze the factors…

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Biomarkers of folate and vitamin B12 and breast cancer risk: Report from the EPIC cohort

Artículos Científicos

Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491…

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Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes

Artículos Científicos

Importance  Low-density lipoprotein cholesterol (LDL-C)–lowering alleles in or near NPC1L1 or HMGCR, encoding the respective molecular targets of ezetimibe and statins, have previously been used as proxies to study the efficacy of these lipid-lowering drugs. Alleles near HMGCR are associated with a higher risk of type 2 diabetes, similar to the increased incidence of new-onset…

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Relationship between physical activity and weight status in adults: a multinomial hierarchical analysis

Artículos Científicos

Se observa una asociación inversa significativa entre la actividad física y la obesidad Obesity, which in itself is a long-term disease, is at the same time a risk factor in the development of serious pathologies such as ischaemic heart disease, hypertension, hypercholesterolaemia and respiratory insufficiency.1 In developed countries, the prevalence of this disease has risen…