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Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background Perfluoroalkyl substances (PFASs) have been related to neurodevelopmental toxicity in animals. However, human studies are inconclusive. Objectives To evaluate the association between prenatal PFAS exposure and neuropsychological development during childhood. Methods 1240 mother–child pairs from the Spanish INMA Project were analyzed. Perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA)…

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Pregnancy Disorders: A Potential Role for Mitochondrial Altered Homeostasis

Artículos Científicos, Cáncer, Investigación

Pregnancy is a complex and challenging process associated with physiological changes whose objective is to adapt the maternal organism to the increasing energetic requirements due to embryo and fetal development. A failed adaptation to these demands may lead to pregnancy complications that threaten the health of both mothers and their offspring. Since mitochondria are the…

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Predictive Model and Mortality Risk Score during Admission for Ischaemic Stroke with Conservative Treatment

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background: Stroke is the second cause of mortality worldwide and the first in women. The aim of this study is to develop a predictive model to estimate the risk of mortality in the admission of patients who have not received reperfusion treatment. Methods: A retrospective cohort study was conducted of a clinical–administrative database, reflecting all…

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Predicting circulating CA125 levels among healthy premenopausal women

Artículos Científicos

Background: CA125 is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study…

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Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk. Objectives To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies. Methods Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95%…

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Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Selenium (Se) may help prevent breast cancer (BC) development. Owing to limited observational evidence, we investigated whether prediagnostic Se status and/or variants in the selenoprotein genes are associated with BC risk in a large European cohort. Se status was assessed by plasma measures of Se and its major circulating proteins, selenoprotein P (SELENOP) and glutathione…

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Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Artículos Científicos

Background: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and…

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Prediagnostic Plasma Nutrimetabolomics and Prostate Cancer Risk: A Nested Case–Control Analysis Within the EPIC Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background and Objective: Nutrimetabolomics may reveal novel insights into early metabolic alterations and the role of dietary exposures on prostate cancer (PCa) risk. We aimed to prospectively investigate the associations between plasma metabolite concentrations and PCa risk, including clinically relevant tumor subtypes. Methods: We used a targeted and large-scale metabolomics approach to analyze plasma samples…

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Prediagnostic Blood Metal Levels and the Risk of Parkinson’s Disease: A Large European Prospective Cohort

Artículos Científicos, Cáncer, Investigación

Background Metals have been postulated as environmental concerns in the etiology of Parkinson’s disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality. Objective The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk. Methods A case-control study was nested…