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Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer

Artículos Científicos

The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC…

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Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer. Methods In the European Prospective Investigation into Cancer and Nutrition (EPIC)…

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Prospective association of liver function biomarkers with development of hepatobiliary cancers

Artículos Científicos

Introduction Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10…

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Prospective analysis of circulating metabolites and endometrial cancer risk

Artículos Científicos, Investigación, Mujeres EASP

Background Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer…

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Prospective analysis of circulating metabolites and breast cancer in EPIC

Artículos Científicos

Background Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive…

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Propuestas para la orientación comunitaria de la atención primaria: identificar agentes clave para la formación

Artículos Científicos

Objetivo Identificar las fortalezas disponibles para la orientación comunitaria de la atención primaria de salud (APS) en el contexto de la evaluación del pilotaje de un programa formativo en salud comunitaria para especialistas internos residentes en Andalucía. Método Estudio cualitativo explicativo de diseño fenomenológico, en el que se analiza la opinión de las personas participantes,…

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Prolactin Determinants in Healthy Women: A Large Cross-Sectional Study within the EPIC Cohort

Artículos Científicos

Background: Experimental and epidemiologic data suggest that higher circulating prolactin is associated with breast cancer risk; however, how various risk factors for breast cancer influence prolactin levels in healthy women is not clear. Methods: We analyzed cross-sectional associations between several suggested reproductive and lifestyle risk factors for breast cancer and circulating prolactin among pre- and…

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Projecting Pharmaceutical Expenditure in EU5 to 2021: Adjusting for the Impact of Discounts and Rebates

Artículos Científicos

Background Within (European) healthcare systems, the predominant goal for pharmaceutical expenditure is cost containment. This is due to a general belief among healthcare policy makers that pharmaceutical expenditure—driven by high prices—will be unsustainable unless further reforms are enacted. Objective The aim of this paper is to provide more realistic expectations of pharmaceutical expenditure for all…

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Progress and challenges in tobacco control policies in Mexico, 2003–2017: an approach using the Tobacco Control Scale

Artículos Científicos

The study aims to assess the implementation of tobacco control policies in Mexico from 2003 through 2017 using the Tobacco Control Scale (TCS). The TCS is a research tool widely used in the European region. It facilitates assessment of tobacco control policy implementation based on six cost-effective interventions: tobacco taxes, smoke-free policies, advertising bans, public…