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Relationship between exposure to mixtures of persistent, bioaccumulative, and toxic chemicals and cancer risk: A systematic review

Artículos Científicos

Environmental risks are responsible for one in five of all deaths worldwide. Persistent, bioaccumulative, and toxic substances are chemicals that can subsist for decades in human tissues and the environment. They include heavy metals, organochlorines, polychlorinated biphenyls, organobromines, organofluorines, and polycyclic aromatic hydrocarbons among others. Although humans are often exposed to multiple pollutants simultaneously, their…

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Regional Versus Centralized Hta: Implications for the Assessment of Cancer Drugs

Artículos Científicos

Different jurisdictions organize their health technology assessment (HTA) capacity in different ways. In theory, a centralized approach offers the potential to pool the scarce resources devoted to HTA and national recommendations can be issued to encourage a uniform development of services across the whole country. On the other hand, a regional approach could help in…

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Reflexiones sobre cómo evaluar y mejorar la respuesta a la pandemia de COVID-19

Artículos Científicos

La pandemia de COVID-19ha afectado de manera particularmente intensa a España, pese a su nivel de desarrollo y la elogiada solidez de su Sistema Nacional de Salud. Para comprender qué ha pasado e identificar cómo mejorar la respuesta creemos imprescindible una evaluación independiente multidisciplinaria de la esfera sanitaria, política y socioeconómica. En este trabajo proponemos…

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Redes personales de apoyo y cuidado informal: ¿diferencias por sexo y territorio? (estudio CUIDAR-SE II)

Artículos Científicos

Objetivo Comparar la composición y la funcionalidad de apoyo social de redes personales de personas cuidadoras de Granada y Gipuzkoa en función del sexo y la provincia. Método Estudio transversal con metodología de análisis de redes personales. Se seleccionó una muestra de 66 personas cuidadoras segmentada por sexo en cada provincia. Se recogieron variables de…

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Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Artículos Científicos

Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: To investigate the association between red blood cell (RBC) membrane FAs and…

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Recognizing a Heart Attack: Patients’ Knowledge of Cardiovascular Risk Factors and Its Relation to Prehospital Decision Delay in Acute Coronary Syndrome

Artículos Científicos

In acute coronary syndromes (ACSs), longer decision delay – the time patients wait before seeking medical attention after symptoms have started – increases the risk of complications and death. However, many patients wait much longer than recommended and research is needed investigating how patient decision delay can be reduced. In a cross-sectional study of 120…

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Recesión bibliográfica: Health technology assessment and health policy today: a multifaceted view of their unstable crossroads

Artículos Científicos

Recensión bibliográfica Del Llano Señarís JE, Campillo-Artero C, directores. Health technology assessment and health policy today: a multifaceted view of their unstable crossroads. En: Ortún V, director. Colección «Economía de la salud y gestión sanitaria». Madrid: Springer Healthcare Communications Ibérica; 2014. 156 p. ISBN: 978-84-940118-5-6

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Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort

Artículos Científicos

Background Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by osteoprotegerin (OPG). We have previously shown that circulating soluble RANKL (sRANKL) and OPG are associated with breast cancer risk. Here we extend these findings…

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Reasons for low cervical cancer survival in new accession European Union countries: a EUROCARE-5 study

Artículos Científicos

Purpose With better access to early diagnosis and appropriate treatment, cervical cancer (CC) burden decreased in several European countries. In Eastern European (EE) countries, which accessed European Union in 2004, CC survival was worse than in the rest of Europe. The present study investigates CC survival differences across five European regions, considering stage at diagnosis…

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Rare thyroid malignancies in Europe: Data from the information network on rare cancers in Europe (RARECAREnet)

Artículos Científicos

Objective Limited information is available on the incidence of rare thyroid cancer (TC) subtypes: anaplastic (ATC) and medullary (MTC). The aim of this study was to describe incidence variations and trends across European countries of all TC subtypes. Materials and methods We used the RARECAREnet database including 80721 TC incident cases in the period 2000–2007…