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Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts

Artículos Científicos

Background Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction. Methods We built two models, for ER+ (ModelER+) and ER- tumors (ModelER-), respectively, in 281,330 women (51%…

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Risk of suicide in households threatened with eviction: the role of banks and social support

Artículos Científicos

Background One of the greatest effects of the financial crisis in Spain has been the enormous increase in the number of evictions. Several studies have shown the association of evictions with different aspects of the physical and mental health. Furthermore, evictions have been associated with an increased risk of suicide. Our objective was to evaluate…

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Review and Assessment of Policy Options for Improving Access to Combination Therapies in Oncology in Europe

Artículos Científicos

Objectives Combinations of on-patent therapies (CTs) are increasingly common in oncology. They cause challenges for funding and affordability, and hence patient access, especially when constituent therapies are owned by different manufacturers. The aim of our study was to develop policy proposals for the assessment, pricing, and funding of CTs and identify which might be relevant…

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Reticencia vacunal: análisis del discurso de madres y padres con rechazo total o parcial a las vacunas

Artículos Científicos

Objetivo Analizar y comprender los discursos reticentes a la vacunación, particularmente los de las personas que han decidido no vacunar a sus hijos/as. Métodos Estudio cualitativo con cinco entrevistas individuales y dos grupos focales con personas que optaron por no vacunar a su hijos/as en la provincia de Granada. Resultados Padres y madres manifiestan un…

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Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk

Artículos Científicos

Circulating pyridoxal-5′-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to…

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Respuesta a la crisis sanitaria de la COVID-19 desde la perspectiva de género: lecciones aprendidas

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Objetivo Profundizar desde la perspectiva de género en las lecciones aprendidas durante la pandemia de COVID-19 para hacer frente a futuras crisis de salud. Método Estudio con informantes clave con experiencia en salud pública y género del Ministerio de Sanidad, Consejerías de las comunidades autónomas, Institut Català de la Salut, Hospital de La Princesa, Escuela Andaluza…

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Resintonizar roles profesionales para la acción comunitaria en tiempos de la COVID-19. Reflexiones desde el Observatorio de Salud Comunitaria

Artículos Científicos

Introducción: La pandemia de la COVID-19 ha generado nuevas barreras a la acción comunitaria en salud, pero también ha potenciado el desarrollo de iniciativas ciudadanas para responder colectivamente a la crisis social y sanitaria. En este contexto se crea el Observatorio de Salud Comunitaria y COVID-19 (OBSCOMCOVID), un espacio en el que personas vinculadas a…

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Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study

Artículos Científicos

Background Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in women. Our objective was to assess the relation of reproductive characteristics with all-cause and cause-specific mortality risk. Methods The analysis was performed within the European Investigation into Cancer and Nutrition prospective cohort study, which…

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Reproductive factors and epithelial ovarian cancer survival in the EPIC cohort study

Artículos Científicos

BACKGROUND: Reproductive factors influence the risk of developing epithelial ovarian cancer (EOC), but little is known about their association with survival. We tested whether prediagnostic reproductive factors influenced EOC-specific survival among 1025 invasive EOC cases identified in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, which included 521 330 total participants (approximately 370 000 women)…